Sakon Nakhon Province, Nakhon Phanom Province, and Mukdahan Province do not have only Buddhist travel routes, but also a path of Christian faith that is equally fascinating, because there are Christian churches, Thai Christian monuments, and communities in many places in these three provinces:

       - St. Anna Church, Nong Saeng, Muang District, Nakhon Phanom Province, is a Roman Catholic Church with unusual architecture: the double spire has a bridge connecting them. This church is a symbol of an international city, because Nakhon Phanom has Christians of various nationalities living there, such as people from Laos and China.

       - St. Joseph Church, Ban Khamkerm, Muang District, Nakhon Phanom Province, is the third Catholic temple in the Northeast, completed in 1907, and it is now the oldest in the Northeast, as the first two are no longer in existence. It features Western and Eastern architecture.

     - Our Lady of the Martyrs, or Wat Song Khon, Wan Yai District, Mukdahan Province, is a Roman Catholic church located on the banks of the Mekong River, built as a memorial in honor of the Seven Blessed Ones who sacrificed their lives in World War II to confirm their belief in the Lord, with a beautiful architectural style that received the Outstanding Architecture Award from the Association of Siamese Architects under the Royal Patronage of His Majesty the King Rama IX in 1996.

       - Ban Tha Rae Community Sakon Nakhon is the largest Roman Catholic community in Thailand, whose people migrated from the city of Sakon Nakhon in the reign of King Rama V by building large bamboo rafts that carried them and their possessions down to the northern shore of Nong Han Lake, which was filled with dirt and called "Hin Hae.” Then, a new community was built and called "Tha Rae," which is when they constructed the Archangel Michael's Cathedral, Tha Rae, a boat-shaped church built as a symbol to commemorate the immigration and settlement of Christians in Tha Rae village.